Cellesce has developed a new bioprocessing technology for the growing and expansion of organoids. Our process yields high quality organoids, with low batch-to-batch variation – in the quantities required for commercial use.
Cellesce expands a range of colorectal cancer and other organoids for applications in drug discovery and for other research applications where large quantities of organoids are consistently required to enable drug discovery. Our initial panels of colorectal organoids originating from our biobank partners are available for expansion in our proprietary biopocessors.
We will soon be adding further organoids derived from other tissues and normal colorectal organoid lines to our product range. Visit our products & services page to find out more.
Revolutionising Cancer Drug Discovery
Organoid models are a powerful new platform technology to enable cancer drug discovery. Organoids are closer to 3D in vivo tissue structures than more conventional 2D cell lines and can provide more relevant pharmacological responses to drugs and antibodies. By using organoids in drug discovery screening assays, scientists can identify active compounds for further progression earlier in the process and weed out less attractive compounds before incurring higher downstream costs.
Cellesce is expert in bioprocessing and 3D cell culture including the growing and expansion of organoids. We can assist with the design and development of bioreactors and peripheral systems for a variety of use cases. Please contact us for further information.
3D bioprocessing capability
The Cellesce team comprises experts in biochemical engineering, bioreactors and associated technologies. We use this capability to build scalable processes to take new therapies from the laboratory to the clinic.
Cellesce is leveraging the output of research programmes and associated capability at University of Bath, Cardiff University and the Hub. This research is currently focused on mammary and intestinal organoids which provide a powerful new approach to high throughput drug screening and could ultimately be used in precision medicine.
Organoid processing technology
Cellesce has built a scalable (patent pending) process for the expansion of organoids. Organoids are 3D cell structures grown from stem cells with organ-like characteristics that retain multiple features of normal and diseased tissues. We are exploring opportunities to deploy this technology across a range of applications.